全文获取类型
收费全文 | 40716篇 |
免费 | 3445篇 |
国内免费 | 2320篇 |
出版年
2023年 | 417篇 |
2022年 | 456篇 |
2021年 | 1736篇 |
2020年 | 1221篇 |
2019年 | 1504篇 |
2018年 | 1409篇 |
2017年 | 1085篇 |
2016年 | 1624篇 |
2015年 | 2428篇 |
2014年 | 2849篇 |
2013年 | 3096篇 |
2012年 | 3589篇 |
2011年 | 3402篇 |
2010年 | 1947篇 |
2009年 | 1799篇 |
2008年 | 2089篇 |
2007年 | 1867篇 |
2006年 | 1605篇 |
2005年 | 1421篇 |
2004年 | 1200篇 |
2003年 | 1055篇 |
2002年 | 904篇 |
2001年 | 847篇 |
2000年 | 736篇 |
1999年 | 711篇 |
1998年 | 416篇 |
1997年 | 452篇 |
1996年 | 429篇 |
1995年 | 389篇 |
1994年 | 378篇 |
1993年 | 309篇 |
1992年 | 441篇 |
1991年 | 383篇 |
1990年 | 331篇 |
1989年 | 246篇 |
1988年 | 236篇 |
1987年 | 198篇 |
1986年 | 142篇 |
1985年 | 185篇 |
1984年 | 121篇 |
1983年 | 104篇 |
1982年 | 80篇 |
1981年 | 60篇 |
1980年 | 55篇 |
1979年 | 73篇 |
1978年 | 66篇 |
1977年 | 46篇 |
1976年 | 48篇 |
1975年 | 40篇 |
1973年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
101.
ABSTRACT: BACKGROUND: Traditional electroencephalography provides a critical assessment of pain responses. The perception of pain, however, may involve a series of signal transmission pathways in higher cortical function. Recent studies have shown that a mathematical method, the neuronal avalanche model, may be applied to evaluate higher-order network dynamics. The neuronal avalanche is a cascade of neuronal activity, the size distribution of which can be approximated by a power law relationship manifested by the slope of a straight line (i.e., the alpha value). We investigated whether the neuronal avalanche could be a useful index for nociceptive assessment. FINDINGS: Neuronal activities were recorded with 4 X 8 multichannel electrode arrays in the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC). Under light anesthesia, peripheral pinch stimulation increased the slope of the alpha value in both the ACC and S1, whereas brush stimulation increased the alpha value only in the S1. The increase in alpha values was blocked in both regions under deep anesthesia. The increase in alpha values in the ACC induced by peripheral pinch stimulation was blocked by medial thalamic lesion, but the increase in alpha values in the S1 induced by brush and pinch stimulation was not affected. CONCLUSIONS: The neuronal avalanche model shows a critical state in the cortical network for noxious-related signal processing. The alpha value may provide an index of brain network activity that distinguishes the responses to somatic stimuli from the control state. These network dynamics may be valuable for the evaluation of acute nociceptive processes and may be applied to chronic pathological pain conditions. 相似文献
102.
Tardrabassus pakneunensis, n. gen. & sp. is described and illustrated. The new genus shows morphological affinities to three leafhopper subfamilies, Tartessinae, Deltocephalinae, and Iassinae, but is tentatively placed in Iassinae based on the position of the ocelli, the reduced lateral frontal sutures, the leg chaetotaxy, and the structure of the male genitalia. 相似文献
103.
104.
105.
Proteins containing the BTB (Bric-à-brac, tramtrack, and Broad Complex) domain typically share low sequence similarities and are involved in a wide range of cellular functions. We previously identified two putative and closely related BTB genes, BTB1 and BTB2, in the genome of the predatory mite Metaseiulus occidentalis. In the current study, full-length BTB1 and BTB2 cDNAs were cloned and sequenced. BTB1 and BTB2 encode proteins of 380 and 401 amino acids, respectively. BTB1 and BTB2 proteins each contain an N-terminal BTB domain and no other identifiable domains. Thus, they belong to a large category of BTB-domain proteins that are widely distributed in eukaryotes, yet with largely unknown function(s). BTB1 and BTB2 gene knockdowns in M. occidentalis females using RNAi reduced their fecundity by approximately 40% and 73%, respectively, whereas knockdown had no impact on their survival or the development of their offspring. These findings suggest these two proteins may be involved in processes related to egg production in this predatory mite, expanding the list of functions attributed to these diverse proteins. 相似文献
106.
The microstructure of the main longitudinal veins of the dragonfly wing and the aerodynamic behaviors of the wing were investigated in this paper.The microstructure of longitudinal vein presents two circumferential chitin layers and a protein-fiber soft layer.The dragonfly wing is corrugated due to the spatial arrangement of longitudinal veins.It was found that the corrugation angle could significantly influence the lift/drag ratio across a range of attack angles by the wind tunnel experiments.The results of the finite element analysis indicate that the protein soft layer of vein facilitates the change of the corrugation angle by allowing substantial relative twisting deformation between two neighboring veins,which is not possible in veins without a soft sandwich layer. 相似文献
107.
108.
109.
110.
Despite our extensive knowledge of insulin-like growth factor 1 (IGF1) action on the growing skeleton, its role in skeletal homeostasis during aging and age-related development of certain diseases is still unclear. Advanced glycation end products (AGEs) derived from glucose are implicated in osteoporosis and a number of diabetic complications. We hypothesized that because in humans and rodents IGF1 stimulates uptake of glucose (a glycation substrate) from the bloodstream in a dose-dependent manner, the decline of IGF1 could be associated with the accumulation of glycation products and the decreasing resistance of bone to fracture. To test the aforementioned hypotheses, we used human tibial posterior cortex bone samples to perform biochemical (measurement of IGF1, fluorescent AGEs and pentosidine (PEN) contents) and mechanical tests (crack initiation and propagation using compact tension specimens). Our results for the first time show a significant, age-independent association between the levels of IGF1 and AGEs. Furthermore, AGEs (fAGEs, PEN) predict propensity of bone to fracture (initiation and propagation) independently of age in human cortical bone. Based on these results we propose a model of IGF1-based regulation of bone fracture. Because IGF1 level increases postnatally up to the juvenile developmental phase and decreases thereafter with aging, we propose that IGF1 may play a protective role in young skeleton and its age-related decline leads to bone fragility and an increased fracture risk. Our results may also have important implications for current understanding of osteoporosis- and diabetes-related bone fragility as well as in the development of new diagnostic tools to screen for fragile bones. 相似文献